NanoDLS, Particle Size Analyzer for Flow & Batch Mode Application by Brookhaven Instruments

NanoDLS, Particle Size Analyzer for Flow & Batch Mode Application by Brookhaven Instruments from Brookhaven Instruments Corporation

By: Brookhaven Instruments Corporation  02/06/2010
Keywords: instruments, Chromatography, analyzers


The NanoDLS is the gateway to absolute nanoparticle sizing including proteins and their aggregates (oligomers), polymers, dendrimers, micelles, and other colloidal materials. Either online ( or SEC/GPC), or in batch-mode, it is an excellent tool for determination of hydrodynamic radii from 0.5 nm to a few microns.

Based on the principles of dynamic light scattering, the NanoDLS uses an automatic, variablepower laser at 638 nm, maximum 35 mW power, a patented* optical cell design, a single-mode fiber, a self-protecting avalanche photodiode and a 25ns/522-channel digital autocorrelator. Due to the patented* cell, the NanoDLS can measure samples from extremely low to high concentrations. Such a design allows for small volumes and a vertical flow pattern, minimizing the effects of bubbles.

For globular proteins and other rare samples, sizes are often small and concentrations low. Because of its unique and patented cell design, the NanoDLS makes obtaining reliable data from such samples easy. In addition aggregate (oligomer) formation is readily probed because light scattering is supremely sensitive to small amounts of larger species.

The NanoDLS is a superb addition to existing and new chromatography systems for the characterization of proteins and polymers since the instrument enables particle sizing without column or instrument calibration. The high sensitivity and small-volume cell allows for low sample concentrations and small injection volumes. These features lead to accurate, absolute data from minute amounts of sample.

Keywords: analyzers, Chromatography, instruments, particle size analysis

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